How to fit a hill curve on scatterplot

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Aaron Ouyang
Aaron Ouyang on 14 Jul 2022
Commented: Aaron Ouyang on 15 Jul 2022
Hi,
I've been plotting dose-response curves of the concentration of a drug vs. the response. I want to insert a binding curve based on the Hill equation on top of my scatterplot and was wondering how I can fit this curve on my graph. Here's the equation that I've been referring to and I've also been looking into custom matlab functions like this, but I've haven't really had much success. Here's my code and graph:
scatter(conc_nm_5ht,resp_conc_5ht)
set(gca, 'XScale', 'log')
Thanks!

Answers (1)

Rishita
Rishita on 15 Jul 2022
mx = 0;
mn = 1;
ec50 = 0.25;
n=5;
x=0:.01:1;
y = mn + (mx-mn)*ec50^n./(ec50^n+x.^n);
plot(x,y)
grid on
Try this
  1 Comment
Aaron Ouyang
Aaron Ouyang on 15 Jul 2022
Thanks.
That generates a generic sigmoidal curve. How can I get it to fit my data specifically though?

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