Biologics PBPK model builder for Matlab SimBiology

version 7.3 (7.76 MB) by Armin Sepp
This is an updated script for rapid assembly of two-pore biologics PBPK models in SimBiology. Brief introduction/description is provided.

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Updated Sun, 12 Jun 2022 17:46:42 +0000

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Two-pore physiologically-based pharmacokinetics (PBPK) for biologics describes the tissue distribution and elimination kinetics of soluble proteins as a function of their hydrodynamic radius and the physiological properties of the organs. Any size, valency, affinity can be implemented. Model is automatically buildt for mouse, rat, monkey and human variants.
PBPKassembler is a a collection of scripts that allows rapidly to build and debug highly customizable cross-modality/cross-species biologics PBPK models for SimBiology.
Version 7.3 follows full compatibility with Matlab 2022a abut is expected to be compatible also with earlier versions. Specifically, in the previous version 5.0 (https://uk.mathworks.com/matlabcentral/fileexchange/82144-biologics-pbpk-model-builder-for-matlab-simbiology?s_tid=srchtitle) the properties of the molecular species were specifiable in SimBiology GUI 'Tag' field, which is no longer directly accessible in version 2020a and later. Instead, the 'Notes' field is now used for the same purpose. A brief introduction/description is added.
All other features are unchanged. The script requires SimBiology Toolbox and final model is fully Matlab/SimBiology compliant.

Cite As

Armin Sepp (2022). Biologics PBPK model builder for Matlab SimBiology (https://www.mathworks.com/matlabcentral/fileexchange/113155-biologics-pbpk-model-builder-for-matlab-simbiology), MATLAB Central File Exchange. Retrieved .

Sepp, A., et al. (2019). "Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats." Journal of Pharmacokinetics and Pharmacodynamics 46(4): 339-359. https://doi.org/10.1007/s10928-019-09640-9

Sepp, A., et al. (2019). "Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats." Journal of Pharmacokinetics and Pharmacodynamics 46(4): 339-359. https://doi.org/10.1007/s10928-019-09640-9

MATLAB Release Compatibility
Created with R2022a
Compatible with any release
Platform Compatibility
Windows macOS Linux

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