If you really want help with this problem, put together a small test suite that gives some inputs and some sample outputs (that you tabulate by hand) and wait for someone to produce a MATLAB function to do what you want.
This is an interesting problem. Acting as an administrator, I cleaned it up and added some tests.
DNA N-Gram Distribution
Back to basics 11 - Max Integer
Back to basics 19 - character types
Back to basics 25 - Valid variable names
Change the sign of even index entries of the reversed vector
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