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Changing the result of a simulation with changing the units
Hi, If the injected amount in model compartments is in mole and the transfer rates are in 1/hour. I set the domensional analys...

4 months ago | 1 answer | 0

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answer

Question


How to find the sensitivity of the model output if it is a variable for repeated assignment?
Hi, I want to find the sensitivity of model output which is a tissue mass for models parameters. I received an red flag that ...

4 months ago | 2 answers | 0

2

answers

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how to handle the error 'Levenberg-Marquardt algorithm the Jacobian at BETA0 is ill-conditioned'?
Hi, I try to run the fit in Simbiology using 'mixed effects' modeling. The transformation is exp(theta1+eta1). The 'error model...

5 months ago | 1 answer | 0

1

answer

Question


Why are population estimated parameters values the same as individual estimated parameters values?
Hi, I good patients data. I did population fit 'mixed effect'. The fits for individual patients were very good but the populati...

5 months ago | 1 answer | 0

1

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Investigating the effect of two covariates to an estimated parameter
Hi, I have data for different patients and I want to investigate the effect of two covariates to an estimated parameter while...

5 months ago | 1 answer | 0

1

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Question


changes the the simulated mass with changing the absolute and relative tolerance
Hi, The mass of the tissue under the effect of a drug goes to very small values, i.e. in the order 10^-12, which is unrealistic...

9 months ago | 1 answer | 0

1

answer

Question


species go to negative values
Hi I developed a model in Simbiology simulating the effect of a drug on a tissue mass. Sometime, I received a message that the...

9 months ago | 2 answers | 0

2

answers

Question


different event functions for the same species
Hi, I developed a model in Simbiology in which Fw is a parameter as a function of mass. The mass varies with time. I wa...

10 months ago | 1 answer | 0

1

answer

Question


A variable is specified by more than one assignment rule
Hi, I have a species A_Total = a + b + c, where a, b and c are other species in the same compartment. I have to set a boundary...

10 months ago | 1 answer | 0

1

answer

Question


Lognormal distribution parameters mu and sigma
Hi, I want to generate a lognormal distribution for a set of data measurments using Simbiology model analyzer. I need to inser...

10 months ago | 3 answers | 0

3

answers

Question


Extracting Histogram data for plot generation
Hi, I generated a sample of lognormal distribution using Simbiology analyzer. I want to extract the data of the samples' hist...

10 months ago | 2 answers | 0

2

answers

Question


Dimensional analysis issue because of the function 'log' in the rule
Hi! When I run a simulation in my model developed in Simbiolog, I received the following warning message: "Unable to perform d...

11 months ago | 1 answer | 0

1

answer

Question


Sensitivity analysis in Simbiology
Hi, I want to perform sensitivity analysis for my Simbiology model. I have encountered the following error. Would you please ex...

1 year ago | 1 answer | 0

1

answer

Question


Change in simulation output with changing in the units of stop time
Hi, I defined units for all parameters in my Smbiology model and the model runs simulations. The unit of time for all paramet...

1 year ago | 1 answer | 0

1

answer

Question


Failure of dimensional analysis for a rule
Hi, I have a rule y=x^0.35. x has the dimension of mass. An error message showed up saying that the exponent must be an integer...

1 year ago | 2 answers | 1

2

answers

Question


Dimension of the species
Hi, In my model in Simbiology, it has a species with dimension of (molecules/time) and connected with a release rate reaction. ...

1 year ago | 1 answer | 0

1

answer

Question


Adding erf(x) to a rule in Simbiology
Hello, I have a rule in my model Y(x) = x, for example, in Simbiology app. I want o add the erf(x) for Y(x) to run a simulati...

1 year ago | 1 answer | 0

1

answer

Question


Simulation error in Simbiology
Hi, I checked the tumor growth model in the library of Simbiology. I noticed if I increase the drug concentration to very high ...

1 year ago | 1 answer | 0

1

answer

Question


Error message regarding CVODES
Hi, While I was running a simulation in a model I developed in Simbiology, I recieved the following error: CVODES returned -...

1 year ago | 0 answers | 0

0

answers

Question


Unites of the transfer rates
Hi, The simulations of my model differ at different unites of transfer rates. For example, the following are plots for the same...

2 years ago | 1 answer | 0

1

answer

Question


Adding equations as a function of time
Hi, Could you please help me in solving the following: I set a trigger event in Simbiology that when 'X' species exceeds a cer...

2 years ago | 1 answer | 0

1

answer

Question


The fluctuation of the content of a species between negative and positive
The model I am developing in Simbiology includes a drug species in which large repeated amounts of doses are injected. It has no...

2 years ago | 1 answer | 0

1

answer

Question


What does a dashed line in simbiology mean?
I found a reaction connecting between two species_1 and species_2 in a simbiology model. There is a dashed line connecting betwe...

2 years ago | 2 answers | 0

2

answers

Question


Adding and configuring events
In simbiology, there is an event trigger that configure events at a SPECIFIC TIME. In my model, the content of m species is numb...

2 years ago | 1 answer | 0

1

answer

Question


How to assign a transfer rate which changes with time in Simbiology?
I need to connect between two species in Simbiology. The transfer rate (k) in the reaction is an equation which depends on time ...

2 years ago | 1 answer | 0

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