I am trying to develop a population pharmacokinetic model using Simbiology,
My settings are
Estimation method: Estimating mixed effects model with nlmefit
Error model is proportional
Method to approximate non-linear mixed effect model likelihood is FOCE.
The FOCE model fitting progress shows a loglikelihood of around -200 (that is good) till iteration of 3500 but after that suddenly the loglikelihood goes to around -900.
Then it keeps on proceeding, untill finally a error comes that the maximum iteration has been obtained. Now the final model has loglikelihood of around -900.
But initially till 3500 iteration, it had a loglikelihood of -200. So finally should i take loglikelihood as -200 or -900?