Why are population estimated parameters values the same as individual estimated parameters values?

Hi,

I good patients data. I did population fit 'mixed effect'. The fits for individual patients were very good but the population fit was not good for a few parameters. How could I solve that?

Also, for a few parameters, the population estimated parameters values were the same as individual estimated parameters values. I don't know why did that happen. How could I solve that?

Thank you.

Answer 1

[Arthur Goldsipe]

Without the actual project, it's difficult to say what's going on. So let me offer some potential explanations for what you're seeing:

• Your model might be incapable of fitting the data for some of the patients.
• Your data might be insufficient for identifying some of the parameters
• The simulation results might be insensitive to some of the parameters.

If you can share your project (publicly or privately), then we could probably offer a more definitive answer.